Lactococcus lactis LL-23 and Reduced Echinococcus multilocularis Infection Burden

• An oral M-cell targeted Lactococcus lactis vaccine against Echinococcus multilocularis infection.

  • 2025-10-28
  • Frontiers in immunology 16
  • • Yang Xiao
    • Zhao-Hui Luo
    • Shun-Juan Wang
    • Yao Dai
    • Jia-Yu Chen
    • Jia-Yong Cui
    • Run-Le Li
    • Feng Tang

  • PubMed: 41229421
  • DOI: 10.3389/fimmu.2025.1683003

  4 Insights on

  • Reduced Echinococcus multilocularis Infection Burden

  • Low evidence
  • Animal Study

  For both primary and secondary infections, oral immunization with LL-plSAM-GILE led to a significant decrease in the diameter and weight of hepatic cysts.

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes