Lactococcus lactis R1058 and Increased Autophagy

• The food grade bacterium Lactobacillus helveticus VEL12193 promotes autophagy by releasing membrane vesicles.

  • 2026-01-06
  • Cell communication and signaling : CCS 24(1)
  • • Marie-Agnès Bringer
    • Simon Manceau
    • Jana Al Azzaz
    • Bénédicte Buteau
    • Lil Proukhnitzky
    • Amaury Aumeunier
    • Luis G Bermúdez-Humarán
    • Florian Chain
    • Catherine Daniel
    • Elise Jacquin
    • Zandile Mlamla
    • Jean-Paul Pais de Barros
    • Julia Novion Ducassou
    • Yohann Couté
    • Guilhem Faure
    • Niyazi Acar
    • Aurélie Rieu
    • Pierre Lapaquette

  • PubMed: 41495832
  • DOI: 10.1186/s12964-025-02616-y

  1 Insight on

  • Increased Autophagy

  • Low evidence

  The Lactobacillus helveticus strain VEL12193, isolated from cheese, emerged as the strongest autophagy inducer. Long-term dietary supplementation of mice with L. helveticus VEL12193 confirmed the pro-autophagic potential of this strain, as evidenced by autophagy stimulation in the gut mucosa but also at distance, in the retina.

  Effect

  Beneficial

  Effect size

  Moderate

• PRKN/parkin-mediated mitophagy is induced by the probiotics Saccharomyces boulardii and Lactococcus lactis.

  • 2023-02-05
  • Autophagy 19(7)
  • • Peter John Hawrysh
    • Jinghua Gao
    • Stephanie Tan
    • Amy Oh
    • Justin Nodwell
    • Thomas A Tompkins
    • G Angus McQuibban

  • PubMed: 36708254
  • DOI: 10.1080/15548627.2023.2172873

  3 Insights on

  • Increased Autophagy

  • Low evidence
  • Animal Study

  We found two probiotics, Saccharomyces boulardii and Lactococcus lactis, that upregulated mitochondrial PRKN recruitment, phospho-ubiquitination, and MFN degradation in our cellular assays.

  Effect

  Beneficial

  Effect size

  Moderate