Lactococcus lactis VPro 34 and Increased Interferon-Alpha Production

• Effects of oral intake of plasmacytoid dendritic cells-stimulative lactic acid bacterial strain on pathogenesis of influenza-like illness and immunological response to influenza virus

  • 2015-08-03
  • RCT · n = 213
  • British Journal of Nutrition 114(5)
  • • Tetsu Sugimura
    • Hitoshi Takahashi
    • K. Jounai
    • Konomi Ohshio
    • Masaya Kanayama
    • Kyoko Tazumi
    • Y. Tanihata
    • Yutaka Miura
    • Daisuke Fujiwara
    • N. Yamamoto

  • PubMed: 26234407
  • DOI: 10.1017/S0007114515002408

  1 Insight on

  • Increased Interferon-Alpha Production

  • High evidence

  IFN-α elicited by A/H1N1 tended to be higher in the JCM5805 group compared with the placebo group, and an IFN-α-inducible antiviral factor, interferon-stimulated gene 15 (ISG15), elicited by A/H1N1 was significantly higher in the JCM5805 group compared with the placebo group after the intake period.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  No