Lactococcus lactis and Increased Hyaluronic Acid Molecular Weight

• Tailored molecular weight hyaluronic acid production by engineered Lactococcus lactis.

  • 2026-02-24
  • Microbial cell factories 25(1)
  • • Sharath Soundiraraj
    • Nakul Ravishankar
    • Pandeeswari Jeeva
    • Lars M Blank
    • Guhan Jayaraman

  • PubMed: 41736074
  • DOI: 10.1186/s12934-026-02945-8

  2 Insights on

  • Increased Hyaluronic Acid Molecular Weight

  • Low evidence

  Compared to their wild-type counterparts, ldh-knockout L. lactis strains showed a noticeable increase in MWHA due to a substantial increase in HA precursor levels.

  Effect

  Beneficial

  Effect size

  Moderate