Paecilomyces hepiali and Reduced Colitis Severity

• Polysaccharides from Paecilomyces hepiali Prevent Acute Colitis in Association with Modulating Gut Microbiota and Treg/Th17 Immune Balance in Mice

  • 2023-06-25
  • Clinical Trial
  • Molecules 28(13)
  • • Luwen Cui
    • Ningning He
    • SHENG ‐ SIUNG Yu
    • Hao Pang
    • Zixuan Zhang
    • Jingyi Wang
    • Jianhua Hao
    • Shangyong Li

  • PubMed: 37446646
  • DOI: 10.3390/molecules28134984

  7 Insights on

  • Reduced Colitis Severity

  • Low evidence
  • Animal Study

  PHP showed significantly preventive potential on dextran sulfate sodium (DSS)-induced colitis in mice, which can prevent colon shortening, reduce intestinal epithelial cell (IEC) destruction, suppress inflammatory cell infiltration

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes