Paecilomyces hepiali and Reduced Hepatic Inflammation Markers

• Paecilomyces hepiali Chen (Cs-4) polysaccharides ameliorate chronic liver fibrosis via inhibiting TGF-β1/Smad and NLRP3/Caspase-1-mediated hepatic stellate cells activation in vivo and in vitro.

  • 2026-03
  • Journal of ethnopharmacology 359
  • • Lumeng Yao
    • Qiuying Xu
    • Yongbin Xu
    • Yue Chen
    • Zhun Xiao
    • Zhenjie Gao
    • Lingyan Zhu
    • Jianjun Wu
    • Luping Qin
    • Siqi Gao

  • PubMed: 41443484
  • DOI: 10.1016/j.jep.2025.121066

  3 Insights on

  • Reduced Hepatic Inflammation Markers

  • Low evidence

  It also decreased serum AST, ALT levels and liver histological injury in mice with chronic liver fibrosis induced by CCl4 and an MCD diet.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes