Paecilomyces hepiali and Reduced Hepatic Stellate Cell Activation

• Paecilomyces hepiali Chen (Cs-4) polysaccharides ameliorate chronic liver fibrosis via inhibiting TGF-β1/Smad and NLRP3/Caspase-1-mediated hepatic stellate cells activation in vivo and in vitro.

  • 2026-03
  • Journal of ethnopharmacology 359
  • • Lumeng Yao
    • Qiuying Xu
    • Yongbin Xu
    • Yue Chen
    • Zhun Xiao
    • Zhenjie Gao
    • Lingyan Zhu
    • Jianjun Wu
    • Luping Qin
    • Siqi Gao

  • PubMed: 41443484
  • DOI: 10.1016/j.jep.2025.121066

  3 Insights on

  • Reduced Hepatic Stellate Cell Activation

  • Low evidence

  It also decreased collagen fiber deposition and HSCs activation... along with a reduction in Col-Ⅰ, α-SMA expressions.

  Effect

  Beneficial

  Effect size

  Large