Pediococcus acidilactici and Reduced Intestinal Inflammation

• Alginate alleviates hyperuricemia by modulating the Pediococcus acidilactici LW1-1-butyrate-NLRP3 inflammasome axis.

  • 2026-04
  • International journal of biological macromolecules 354
  • • Yukun Li
    • Rongshuang Han
    • Rong Wang
    • Xiaoyan Zhang
    • Mengchen Shan
    • Tianyu Fu
    • Yupeng Li
    • Xingsi Qi
    • Bin Cao
    • Yi Wang
    • Tao Mao
    • Zibin Tian

  • PubMed: 41819315
  • DOI: 10.1016/j.ijbiomac.2026.151318

  4 Insights on

  • Reduced Intestinal Inflammation

  • Low evidence
  • Animal Study

  Both P. acidilactici LW1-1 and butyrate suppressed intestinal inflammation by inhibiting nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome activation and enhancing tight junction integrity.

  Effect

  Beneficial

  Effect size

  Moderate