Pediococcus acidilactici and Reduced Uric Acid Levels

• Alginate alleviates hyperuricemia by modulating the Pediococcus acidilactici LW1-1-butyrate-NLRP3 inflammasome axis.

  • 2026-04
  • International journal of biological macromolecules 354
  • • Yukun Li
    • Rongshuang Han
    • Rong Wang
    • Xiaoyan Zhang
    • Mengchen Shan
    • Tianyu Fu
    • Yupeng Li
    • Xingsi Qi
    • Bin Cao
    • Yi Wang
    • Tao Mao
    • Zibin Tian

  • PubMed: 41819315
  • DOI: 10.1016/j.ijbiomac.2026.151318

  4 Insights on

  • Reduced Uric Acid Levels

  • Low evidence
  • Animal Study

  P. acidilactici LW1-1 enriched butyrate-producing bacteria and increased butyrate levels, thereby protecting against intestinal inflammation and barrier dysfunction... Concurrently, these interventions upregulated expression of the urate efflux transporter ABCG2 in the intestine and kidney, thereby promoting UA excretion via dual pathways.

  Effect

  Beneficial

  Effect size

  Large