Propionibacterium freudenreichii MAK10P23F and No Clinically Significant Hematological Changes

• Safety of high doses of Propionibacterium freudenreichii ET-3 culture in healthy adult subjects.

  • 2011-07
  • RCT · n = 25
  • Regulatory Toxicology and Pharmacology 60(2)
  • • M. Uchida
    • H. Tsuboi
    • Masayo Takahashi Arita
    • A. Nemoto
    • Keisuke Seki
    • H. Tsunoo
    • Stephanie Martyres
    • Ashley Nicole Roberts

  • PubMed: 21172397
  • DOI: 10.1016/j.yrtph.2010.12.005

  1 Insight on

  • No Clinically Significant Hematological Changes

  • High evidence
  • Adults

  The changes in hematological parameters were deemed not to be due to P. freudenreichii ET-3 culture medium supplementation given that all parameters remained within normal ranges and were not consistent with any clinically meaningful effect.

  Effect

  Neutral

  Effect size

  Small