Streptococcus salivarius BLIS K12 and Maintained Safety with Repeated Oral Exposure

• In Vitro and In Vivo Safety Evaluation of Streptococcus salivarius eK12, a Genetically Modified Dietary Probiotic Derived from the Oral Probiotic S. salivarius K12.

  • 2025-12-09
  • Journal of microbiology and biotechnology 35
  • • Francesco Di Pierro
    • Gayathri Veeraraghavan
    • Kuppusamy Kalaiselvan
    • Bahrudeen Ashif
    • Logeshwari Jeyakumar
    • Gopikrishnan Gopalakrishnan
    • Massimiliano Cazzaniga
    • Alexander Bertuccioli
    • Maria Laura Tanda
    • Nicola Zerbinati
    • Ikram Ujjan
    • Ali Akbar Bugti
    • Aasiya Bano
    • Yasmeen Gull
    • Nasrin Mumtaz
    • Amjad Khan

  • PubMed: 41391486
  • DOI: 10.4014/jmb.2509.09016

  4 Insights on

  • Maintained Safety with Repeated Oral Exposure

  • Low evidence
  • Animal Study

  These findings indicate that eK12 is potentially non-mutagenic, non-toxic, and well tolerated... retaining the favorable safety profile of its parental strain K12 and supporting its further development.

  Effect

  Beneficial

  Effect size

  Large