Streptococcus salivarius BLIS K12 and No Adverse Health Effects

• In Vitro and In Vivo Safety Evaluation of Streptococcus salivarius eK12, a Genetically Modified Dietary Probiotic Derived from the Oral Probiotic S. salivarius K12.

  • 2025-12-09
  • Journal of microbiology and biotechnology 35
  • • Francesco Di Pierro
    • Gayathri Veeraraghavan
    • Kuppusamy Kalaiselvan
    • Bahrudeen Ashif
    • Logeshwari Jeyakumar
    • Gopikrishnan Gopalakrishnan
    • Massimiliano Cazzaniga
    • Alexander Bertuccioli
    • Maria Laura Tanda
    • Nicola Zerbinati
    • Ikram Ujjan
    • Ali Akbar Bugti
    • Aasiya Bano
    • Yasmeen Gull
    • Nasrin Mumtaz
    • Amjad Khan

  • PubMed: 41391486
  • DOI: 10.4014/jmb.2509.09016

  4 Insights on

  • No Adverse Health Effects

  • Low evidence
  • Animal Study

  Results showed no mutagenic activity, no mortality, and no treatment-related abnormalities in clinical, hematological, biochemical, or histopathological parameters. Minor fluctuations were incidental and non-dose dependent.

  Effect

  Neutral

  Effect size

  Large