Streptococcus salivarius BLIS K12 and Reduced Periodontal Pathogen Burden

• From periodontal infection to oral-systemic dysbiosis: re-framing the oral microbiome's role in systemic health and the prophylactic potential of Streptococcus salivarius probiotics.

  • 2025-12-02
  • Review
  • Frontiers in microbiology 16
  • • Francesco Di Pierro
    • Carlo Fornaini
    • Chiara Maria Palazzi
    • Alexander Bertuccioli
    • John Tagg
    • Nicola Zerbinati

  • PubMed: 41409978
  • DOI: 10.3389/fmicb.2025.1685071

  3 Insights on

  • Reduced Periodontal Pathogen Burden

  • Low evidence

  oral administration of Generally Recognized as Safe (GRAS)-grade probiotic Streptococcus salivarius, such as strain K12, may help restore oral eubiosis

  Effect

  Beneficial

  Effect size

  Small