The potential bactericidal effect of oral probiotics on extrinsic black stain-associated bacteria in children: An in-vitro and in-vivo study.
- 2025-10
- Journal of dental sciences 20(4)
- Nour Wahba
- Dina Sharaf
- Mohamed Wagdy
- Ahmed El-Motayam
- Basma Nagi
- PubMed: 41040574
- DOI: 10.1016/j.jds.2025.04.032
- Low evidence
In the in-vitro study, bacterial growth declined progressively with increasing probiotic concentrations, confirming a dose-dependent inhibitory effect. Statistical analysis showed significant reductions for both species (P < 0.001) compared to controls, with A. actinomycetemcomitans exhibiting a stronger response. In the in-vivo study, A.actinomycetemcomitans was fully eradicated, while A. naeslundii showed only partial suppression.
- Effect
- Beneficial
- Effect size
- Moderate
- Significant
- Yes