Streptococcus salivarius K12 and Delayed Oral Mucositis Onset

• Streptococcus salivarius K12 Alleviates Oral Mucositis in Patients Undergoing Radiotherapy for Malignant Head and Neck Tumors: A Randomized Controlled Trial.

  • 2024-04-20
  • RCT · n = 160
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology 42(12)
  • • Xingchen Peng
    • Zixia Li
    • Yiyan Pei
    • Shuhao Zheng
    • Jinchi Liu
    • Jingjing Wang
    • Ruidan Li
    • Xin Xu

  • PubMed: 38215354
  • DOI: 10.1200/jco.23.00837

  2 Insights on

  • Delayed Oral Mucositis Onset

  • High evidence
  • Large Human Trial

  The duration ... and time to develop SOM (median, not estimable v 42.0 days; hazard ratio, 0.55 [95% CI, 0.34 to 0.89]; log-rank test: P = .0123) were also improved in the case of the SsK12 group.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  thrice daily (lozenges)

• Effectiveness of Streptococcus salivarius probiotics on alleviating radiation-induced oral mucositis via inflammatory and microecological modulation: a prospective pragmatic interventional study in nasopharyngeal carcinoma.

  • 2026-03-03
  • Clinical Trial
  • Frontiers in immunology 17
  • • Xiao-Tong Huang
    • Hui Feng
    • Ye Tan
    • Quan Wang
    • Jie-Mei Wei
    • Zhao-Dong Huang
    • Xin-Tong Wang
    • Hai-Jun Lu

  • PubMed: 41853273
  • DOI: 10.3389/fimmu.2026.1745549

  4 Insights on

  • Delayed Oral Mucositis Onset

  • Moderate evidence

  Compared with non-probiotic group, SsM18 significantly delayed OM onset (p = 0.014), reduced SOM duration (p = 0.019), and shortened total OM duration (p = 0.031), outperforming SsK12.

  Effect

  Neutral

  Effect size

  Small

  Significant

  No