Streptococcus salivarius Probiotics to Prevent Acute Otitis Media in Children: A Randomized Clinical Trial.
- 2023-11-02
- RCT · n = 827
- JAMA network open 6(11)
- Suvi Sarlin
- Ulla Koskela
- Minna Honkila
- Paula A Tähtinen
- Tytti Pokka
- Marjo Renko
- Terhi Tapiainen
- PubMed: 37917062
- DOI: 10.1001/jamanetworkopen.2023.40608
- High evidence
- Large Human Trial
- Rigorous Journal
- Children
Time to first AOM episode did not differ between the groups (174 [95% CI, 171-177] days in the S salivarius group vs 176 [95% CI, 173-179] days in the placebo group; P = .18).
- Effect
- Neutral
- Effect size
- Small
- Significant
- No
- Dose
- 1 × 10^9 colony-forming units daily