Streptococcus salivarius K12 and Reduced Acute Otitis Media Requiring Antimicrobial Therapy

Doses used in studies

CFU/day: 1 billion (median 1 billion, IQR 1 billion–1 billion) — 1 study

Time to effect

Median: 6 months · IQR 6 months–6 months · Range 6 months–6 months — Reported in 1 of 1 study

1 of 1 paper

Streptococcus salivarius Probiotics to Prevent Acute Otitis Media in Children: A Randomized Clinical Trial.

2023-11-02
RCT · n = 827
JAMA network open 6(11)
- Suvi Sarlin
- Ulla Koskela
- Minna Honkila
- Paula A Tähtinen
- Tytti Pokka
- Marjo Renko
- Terhi Tapiainen

PubMed: 37917062
DOI: 10.1001/jamanetworkopen.2023.40608

2 Insights on

Reduced Acute Otitis Media Requiring Antimicrobial Therapy

High evidence
Large Human Trial
Rigorous Journal
Children

Thirty-four children (8.2%) in the S salivarius group and 24 children (5.8%) in the placebo group experienced at least 1 episode of AOM requiring antimicrobial therapy during the 6-month follow-up period (relative risk, 1.42 [95% CI, 0.86-2.34]; proportion difference, -2.44% [95% CI, -5.94% to 1.09%]; P = .17).

Effect: Neutral
Effect size: Small
Significant: No
Dose: 1 × 10^9 colony-forming units daily