Preliminary data revealing efficacy of Streptococcus salivarius K12 (SSK12) in Periodic Fever, Aphthous stomatitis, Pharyngitis, and cervical Adenitis (PFAPA) syndrome: A multicenter study from the AIDA Network PFAPA syndrome registry
- 2023-02-16
- Observational · n = 85
- Frontiers in Medicine 10
- F. La Torre
- J. Sota
- A. Insalaco
- G. Conti
- E. Del Giudice
- R. Lubrano
- L. Breda
- M. Maggio
- A. Civino
- Violetta Mastrorilli
- Robert LoConte
- Marco Francesco Natale
- C. Celani
- Mery Romeo
- S. Patroniti
- Cristina Gentile
- A. Vitale
- V. Caggiano
- C. Gaggiano
- F. Diomeda
- M. Cattalini
- G. Lopalco
- G. Emmi
- P. Parronchi
- S. Gentileschi
- F. Cardinale
- E. Aragona
- F. Shahram
- A. Marino
- P. Barone
- C. Moscheo
- B. Ozkiziltas
- F. Carubbi
- Ohoud AlAhmed
- Ludovica Iezzi
- B. Ogunjimi
- A. Mauro
- M. Tarsia
- Ayman Magdy Ahmed Mahmoud
- Henrique Giardini
- P. Sfikakis
- K. Laskari
- E. Więsik-Szewczyk
- J. Hernández-Rodríguez
- B. Frediani
- Verónica Gómez-Caverzaschi
- A. Tufan
- I. Almaghlouth
- A. Balistreri
- Gaafar Ragab
- Claudia Fabiani
- L. Cantarini
- D. Rigante
- PubMed: 36873863
- DOI: 10.3389/fmed.2023.1105605
- Moderate evidence
Similarly, the highest temperature in °C was found significantly lower in the last follow-up assessment [median (IQR), 39.00 (1.00)] compared to the period prior to SSK12 start [median (IQR), 40.00 (1.00), p < 0.001].
- Effect
- Beneficial
- Effect size
- Moderate
- Significant
- Yes