Streptococcus salivarius K12 and Reduced PFAPA Fever Episode Frequency

• Use of Streptococcus Salivarius K12 in a cohort of PFAPA patients.

  • 2024-07-25
  • Observational · n = 117
  • Frontiers in pediatrics 12
  • • Alessandra Spagnolo
    • Vincenzo Mileto
    • Adele Civino
    • Maria Cristina Maggio
    • Paolo Risso
    • Simona Sestito
    • Romina Gallizzi

  • PubMed: 39119192
  • DOI: 10.3389/fped.2024.1370544

  8 Insights on

  • Reduced PFAPA Fever Episode Frequency

  • High evidence

  Before using SS K12, febrile episodes recurred on average every 26.1 ± 11.5 days... After six months of SS K12, febrile episodes recurred on average every 70 ± 53.1 days (p value <0.01)

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes