Cariogram outcome after 90 days of oral treatment with Streptococcus salivarius M18 in children at high risk for dental caries: results of a randomized, controlled study.

2015-10-03
RCT
Clinical, cosmetic and investigational dentistry 7
- Francesco Di Pierro
- Alberto Zanvit
- Piero Nobili
- Paolo Risso
- Carlo Fornaini

PubMed: 26491371
DOI: 10.2147/ccide.s93066

2 Insights on

Reduced Dental Caries

High evidence

the use of salivarius M18 increases the chances of avoiding new dental caries development in children

Effect: Beneficial
Effect size: Small

From periodontal infection to oral-systemic dysbiosis: re-framing the oral microbiome's role in systemic health and the prophylactic potential of Streptococcus salivarius probiotics.

2025-12-02
Review
Frontiers in microbiology 16
- Francesco Di Pierro
- Carlo Fornaini
- Chiara Maria Palazzi
- Alexander Bertuccioli
- John Tagg
- Nicola Zerbinati

PubMed: 41409978
DOI: 10.3389/fmicb.2025.1685071

3 Insights on

Reduced Dental Caries

Low evidence

Streptococcus salivarius, such as strain K12, may help restore oral eubiosis and potentially reduce systemic inflammatory burden. While the hypothesis that oral probiotic maintenance may reduce the risk of systemic disorders remains to be clinically verified...

Effect: Beneficial
Effect size: Small