Streptococcus salivarius and Reduced Oral Mucositis Severity

• Effectiveness of Streptococcus salivarius probiotics on alleviating radiation-induced oral mucositis via inflammatory and microecological modulation: a prospective pragmatic interventional study in nasopharyngeal carcinoma.

  • 2026-03-03
  • Clinical Trial
  • Frontiers in immunology 17
  • • Xiao-Tong Huang
    • Hui Feng
    • Ye Tan
    • Quan Wang
    • Jie-Mei Wei
    • Zhao-Dong Huang
    • Xin-Tong Wang
    • Hai-Jun Lu

  • PubMed: 41853273
  • DOI: 10.3389/fimmu.2026.1745549

  2 Insights on

  • Reduced Oral Mucositis Severity

  • Moderate evidence

  GBTM identified two distinct OM trajectories: 'Rapid-Onset, Severe' group and 'Late-Onset, Mild' group. Multivariate analysis revealed that elevated log-transformed Interleukin-6 levels ... and high Beck Oral Assessment Scale (BOAS) score ... as independent predictors of 'Rapid-Onset, Severe' trajectory.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes