Streptococcus thermophilus SL-21 and Improved Dry Eye Symptoms

• Oral Intake of Streptococcus thermophilus iHA318 Mitigates Dry Eye Symptoms in a Randomized Clinical Study.

  • 2025-04-10
  • RCT · n = 68
  • Biomedicines 13(4)
  • • Chieh-Hung Yen
    • Yu-Wei Chang
    • Yen-Ling Sun
    • Yi-Yun Hung
    • Wei-Chieh Liao
    • Tsung-Han Lu
    • Pin-Chao Huang
    • Han-Hsin Chang
    • Meei-Yn Lin
    • David Pei-Cheng Lin

  • PubMed: 40299529
  • DOI: 10.3390/biomedicines13040931

  1 Insight on

  • Improved Dry Eye Symptoms

  • High evidence

  The probiotic group showed a significant reduction in tear osmolarity, an extended TBUT, and an improved OSDI score... Reductions in NLRP3 inflammasome activation and OSDI were found only in the probiotic group. In conclusion, a significant improvement in major dry eye symptoms after iHA318 treatment was observed compared to the placebo group.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes