Effect of gluten and wheat on symptoms and behaviours in adults with irritable bowel syndrome: a single-centre, randomised, double-blind, sham-controlled crossover trial.
- 2025-09
- RCT · n = 42
- The lancet. Gastroenterology & hepatology 10(9)
- Caroline Larissa Seiler
- Gaston Horacio Rueda
- Pedro Miguel Miranda
- Andrea Nardelli
- Rajka Borojevic
- Amber Hann
- Sara Rahmani
- Russell De Souza
- Alberto Caminero
- Valentina Curella
- Manjusha Neerukonda
- Stephen Vanner
- Detlef Schuppan
- Paul Moayyedi
- Stephen Michael Collins
- Elena Francisca Verdu
- Maria Ines Pinto-Sanchez
- Premysl Bercik
- PubMed: 40706614
- DOI: 10.1016/s2468-1253(25)00090-1
- High evidence
- Clinical
there were no statistically significant differences in the proportion of participants with a worsening of IBS-SSS of at least 50 points after ... gluten (ten participants [36%], 0·07; -0·19 to 0·32) versus sham (eight participants [29%]).
- Effect
- Neutral
- Effect size
- Small
- Significant
- No