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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Soy Protein and Reduced C-Reactive Protein Levels

Research synthesisLow evidenceModerate effect3 studies · 1 beneficial · 2 neutral · 0 harmful

Across 3 studies, 1 meta-analysis reported a moderate beneficial effect of soy isoflavones containing soy protein on reducing C-reactive protein (CRP) levels in adults with chronic inflammatory diseases, while 2 studies found neutral effects in mixed or clinical populations. The predominant effect direction is beneficial with a moderate effect size, and effects were typically observed over a median duration of 90 days. The evidence base is small, with no clear dose range or specific form identified across studies.

  • Studied populations: adults with chronic inflammatory diseases

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests. The beneficial finding comes from a meta-analysis focused on chronic inflammatory populations, while neutral studies targeted different groups (sarcopenia, pre-frailty, general adults), which may explain the discrepant results.

Generated Jun 11, 2026
Doses used in studies
  • g/day: 40 (median 40, IQR 40–40) — 1 study
Time to effect
Median: 3 months · IQR 3 months–3 months · Range 3 months–3 months — Reported in 1 of 3 studies
3 of 3 papers
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