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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Whey Protein and Increased Insulin-like Growth Factor-1 Level

Doses used in studies

g single-dose: 24 (median 24, IQR 24–24) — 1 study

Time to effect

Median: 2.8 months · IQR 2.8 months–2.8 months · Range 2.8 months–2.8 months — Reported in 1 of 2 studies

2 of 2 papersPopulation:

Improving sarcopenia in older adults: a systematic review and meta-analysis of randomized controlled trials of whey protein supplementation with or without resistance training.
- 2024-04
- Meta-Analysis · n = 1,154
- The journal of nutrition, health & aging 28(4)
- - Ming-Lin Li
  - Fei Zhang
  - Han-Yong Luo
  - Zi-Wei Quan
  - Yi-Fei Wang
  - Le-Tian Huang
  - Jia-He Wang
- PubMed: 38350303
- DOI: 10.1016/j.jnha.2024.100184
13 Insights on
- Increased Insulin-like Growth Factor-1 Level
- High evidence
- Clinical
significantly increased insulin-like growth factor-1
Effect
Beneficial
Effect size
Small
Significant
Yes
Post-Exercise Whey Protein Supplementation: Effects on IGF-1, Strength, and Body Composition in Pre-Menopausal Women, a Randomised Controlled Trial.
- 2025-06-18
- RCT
- Nutrients 17(12)
- - Marc Murray
  - Lara Vlietstra
  - Alyssa M D Best
  - Stacy T Sims
  - James A Loehr
  - Nancy J Rehrer
- PubMed: 40573144
- DOI: 10.3390/nu17122033
6 Insights on
- Increased Insulin-like Growth Factor-1 Level
- High evidence
- Rigorous Journal
- Adults
no change in IGF-1 (-6.0 ± 27.7 µg/L, -2.1 ± 27.8 µg/L, CON, PRO, resp., p = 0.920)
Effect
Neutral
Effect size
Small
Significant
No
Dose
24 g