Whey Protein and Increased Insulin Response

• A randomized controlled trial in healthy participants to compare the insulinogenic effects of whey protein and pea protein co-ingested with glucose.

  • 2026-01-30
  • RCT
  • PloS one 21(1)
  • • Pariyarath Sangeetha Thondre
    • Elysia Young
    • Sam Pledger
    • Sarah Kefyalew
    • Isabel Hatami
    • Caroline Perreau
    • Laetitia Guérin Deremaux
    • Catherine Lefranc-Millot
    • Jonathan Tammam

  • PubMed: 41615946
  • DOI: 10.1371/journal.pone.0340386

  3 Insights on

  • Increased Insulin Response

  • High evidence

  Insulin incremental area under the curve at 180 minutes (µU/ml*min) for glucose with 20 g pea protein (4304.56 ± 1896.07) was significantly lower (p < 0.001) than glucose with 20g whey protein (6311.81 ± 3489.12).

  Effect

  Harmful

  Effect size

  Large

  Significant

  Yes

  Dose

  20 g