Dehydroepiandrosterone (DHEA) is generally considered well-tolerated, but it can cause several side effects. Here are the primary ones to be aware of:

1. Acne and Skin Issues: One of the most common side effects is acne. Some users also report oily skin¹².
2. Hormonal Changes: DHEA can lead to increased testosterone or estrogen levels. This can result in androgenic effects such as facial hair growth and deepened voice in females¹²³.
3. Mood Changes: DHEA can cause excitability, impulsiveness, and irritability, particularly in people with mood disorders².
4. Gastrointestinal Issues: Some users experience upset stomach or gastrointestinal discomfort²⁴.
5. Potential Cancer Risk: Long-term use or higher doses of DHEA might increase the risk of hormone-sensitive cancers such as breast cancer and prostate cancer⁴³.
6. Metabolic Impact: DHEA might lower high-density lipoprotein (HDL or "good") cholesterol levels, which could affect cardiovascular health².
7. Liver Concerns: There is a potential for DHEA to exacerbate liver problems².
8. Special Populations: People with conditions such as diabetes, liver issues, high cholesterol, or hormone-sensitive conditions should exercise caution and consult a healthcare provider before using DHEA².

It's advisable to start with a lower dose and monitor for any adverse effects, and always consult with a healthcare professional before adding a new supplement to your regimen.

Footnotes

1. DHEA: Examine.com ↩ ↩²

2. DHEA: MedlinePlus Supplements ↩ ↩² ↩³ ↩⁴ ↩⁵ ↩⁶ ↩⁷

3. Update on the use of dehydroepiandrosterone supplementation among women with diminished ovarian function ↩ ↩²

4. Possible dihydroepiandrosterone-induced mania ↩ ↩²