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Navigating Chronic Fatigue: Exploring Intrinsic Factor and Vitamin B12 Supplement Solutions

A user shares their struggle with chronic fatigue and the discontinuation of their preferred B Complex supplement with intrinsic factor. The assistant discusses the role of intrinsic factor in B12 absorption, alternative supplementation options, and the effectiveness of high-dose B12 without intrinsic factor.

  • So, years ago (2017ish) I had another round of chronic fatigue and after digging I did find out about Intrinsic factor and starting using DOUGLAS LABORATORIES B Complex WITH Intrinsic Factor.. That, along with D3 supplementation and a KETO diet.

    There was a nice window where I felt great. My mood, energy, all improved. all inflammation in my joints went away. I had no anxiety.. I just felt NORMAL.. that lasted for a few months and then went down .. and then the pandemic hit and everything went wompus.

    around 2020 I was trying to get my supplement on Amazon and elsewhere and they no longer carried it. I even called Douglas Labs to ask if they would be producing more and they said no.. :(.

    I see a couple of other supplements with Intrinsic factor, one that i seem to ahve tried but don't know why I didn't continue.. (was it not working as well? I o don't know)l.

    So here I am AGAIN with another round of fatigue and issues. I am on Adderal as well as Carbanazapene and I take Estradiol and Progsterone. I have ADHD and finances are tight so trying to remain consistant with a good solid protocol has been hard.

    SO has anyone had luck with an intrinsifc factor supplement?

  • The efficacy of intrinsic factor supplements, typically included in vitamin B12 formulations, has received some attention in scientific research. Intrinsic factor is a protein produced in the stomach that aids in the absorption of vitamin B12 in the small intestine12. For people who have trouble absorbing vitamin B12 from food (due to conditions like pernicious anemia or atrophic gastritis), intrinsic factor can play a critical role in enabling the body to utilize this vitamin34.

    However, research also suggests that high doses of oral vitamin B12 can be absorbed through passive diffusion, bypassing the need for intrinsic factor altogether5. This has implications for those who cannot produce intrinsic factor efficiently.

    Another aspect covered in studies is the comparison of different forms of vitamin B12, such as cyanocobalamin and methylcobalamin, with cyanocobalamin often showing better results in maintaining adequate serum B12 levels[^6].

    To summarize:

    • Intrinsic factor supplements can be particularly beneficial for individuals with specific absorption issues.
    • High-dose oral vitamin B12 supplements can sometimes compensate for the lack of intrinsic factor, as a portion of vitamin B12 is absorbed passively.
    • The form of vitamin B12 (such as cyanocobalamin) may influence the effectiveness of supplementation.

    Given your past positive experiences with the Douglas Laboratories B Complex with Intrinsic Factor, you might consider looking for other high-quality B12 supplements that include intrinsic factor or high-dose B12 supplements that can be absorbed passively.

    Would you like me to search for some relevant products for you?

    Footnotes

    1. Fiona O’Leary, "Vitamin B12 in Health and Disease" (2010) NCBI ↩

    2. A S M Al Amin, "Vitamin B12 (Cobalamin) - StatPearls" (2021) NCBI ↩

    3. Fiona O’Leary, "Vitamin B12 in Health and Disease" (2010) NCBI ↩

    4. A S M Al Amin, "Vitamin B12 (Cobalamin) - StatPearls" (2021) NCBI ↩

    5. A S M Al Amin, "Vitamin B12 (Cobalamin) - StatPearls" (2021) [NC ↩

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