Skip to main content
Evidence-Based Supplement Research
Evidence-Based Supplement Research
Pillser
Search
Sign UpLog In

Does Clostridium butyricum Lower Interferon-Gamma Levels? Exploring Anti-Inflammatory Effects

A user asks whether Clostridium butyricum can reduce inflammation by lowering interferon-gamma (IFN-γ) levels. The assistant confirms, citing a randomized controlled trial showing significant IFN-γ reduction in elderly with malnutrition, plus broader anti-inflammatory effects on IL-6, TNF-α, and IL-10.

  • I've heard Clostridium butyricum might help reduce inflammation—does it actually lower something like interferon-gamma levels in the body?

  • Yes, there is evidence that Clostridium butyricum can help lower interferon-gamma (IFN-γ) levels in the body. Here's what the research shows:

    Key Finding from Clinical Research

    A randomized controlled trial from 2022 investigated Clostridium butyricum supplementation in elderly people with malnutrition and found that proinflammatory factor interferon-gamma (IFN-γ) levels decreased significantly (p < 0.05) throughout the intervention period1.

    Broader Anti-Inflammatory Effects

    Beyond IFN-γ, Pillser's research database also shows that Clostridium butyricum has been studied for its broader anti-inflammatory effects. A 2026 study found that it helped reduce levels of pro-inflammatory cytokines IL-6 and TNF-α, while increasing the anti-inflammatory cytokine IL-10, in the context of atherosclerotic inflammation2. This is thought to work, in part, through modulation of the gut microbiota2.

    Summary of Pillser Research Data

    OutcomeStudiesBeneficialNeutralHarmful
    Reduced Inflammation1 study100
    Reduced IFN-γ Levels1 study (RCT)100

    So to answer your question directly: Yes, Clostridium butyricum has been shown in a clinical trial to significantly lower interferon-gamma levels, alongside other markers of inflammation.

    Footnotes

    1. Pillser research database, Clostridium butyricum and Reduced Interferon-gamma Level — 1 randomized controlled trial with significant IFN-γ reduction. ↩

    2. Pillser research database, Clostridium butyricum and Reduced Inflammation — 1 study showing decreased IL-6, TNF-α, and increased IL-10. ↩ ↩2

New Topic

Browse Related Questions

Back to top