Nicotinamide mononucleotide (NMN) is a precursor to NAD+ (nicotinamide adenine dinucleotide), a crucial molecule involved in energy metabolism and cellular health.

Benefits of NMN Supplements

1. Anti-Aging Effects: NMN supplementation has been shown to increase NAD+ levels, which can mitigate age-associated decline¹². This includes improved energy metabolism, insulin sensitivity, physical activity, mitochondrial function, and other physiological functions.

2. Metabolic Health: Studies have shown that NMN can improve insulin secretion and sensitivity, making it beneficial for conditions such as diabetes³⁴.

3. Muscle Function: Long-term NMN supplementation has been reported to improve muscle function in older adults, enhancing gait speed and grip strength⁵.

4. Brain Health: NMN has protective effects on neuronal function and may slow cognitive decline. It is believed to enhance brain health by improving energy metabolism and reducing oxidative stress⁶.

5. Eye Health: NMN can also ameliorate age-related functional decline in the eyes⁷.

6. Cardiovascular Health: It has been found to protect the heart from ischemia and reperfusion injury⁸.

7. Inflammation Reduction: NMN may help reduce age-associated inflammation, also known as inflammaging⁹.

Safety and Tolerability

Human clinical trials have reported that NMN supplementation is generally safe and well-tolerated¹⁰.

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Footnotes

1. NAD+ intermediates: The biology and therapeutic potential of NMN and NR ↩

2. Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice ↩

3. The Science Behind NMN–A Stable, Reliable NAD+Activator and Anti-Aging Molecule ↩

4. Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men ↩

5. NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health ↩

6. The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update ↩

7. Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice ↩

8. The Science Behind NMN–A Stable, Reliable NAD+Activator and Anti-Aging Molecule ↩

9. Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan ↩

10. Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men ↩