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Top 5 Longevity Supplements Backed by Human Studies for Healthy Aging

Discover five supplements—NMN, NR, Resveratrol, AKG, and low-dose Lithium—proven in human studies to promote longevity and healthy aging. Learn about their benefits, mechanisms, and the scientific research supporting their effectiveness.

  • best 5 supplements proven in human studies for longevity

  • Human studies and reviews suggest several supplements that have shown potential for promoting longevity and healthy aging. Here are five such supplements, backed by reputable research:

    1. Nicotinamide Mononucleotide (NMN):

      • NMN is a precursor to NAD+ (Nicotinamide Adenine Dinucleotide), a coenzyme critical for energy metabolism and cellular health. Supplementation has been shown to enhance insulin sensitivity, improve mitochondrial function, and reduce age-related disease markers1.

    2. Nicotinamide Riboside (NR):

      • Similar to NMN, NR is another NAD+ precursor that has been studied for its benefits in promoting healthy aging. Clinical trials indicate it may improve metabolic function, increase energy, and support cardiovascular health2.

    3. Resveratrol:

      • Found in red wine, grapes, and peanuts, resveratrol has been shown to exert antioxidant, anti-inflammatory, and neuroprotective effects. It may help ameliorate oxidative stress, improve mitochondrial function, and provide cardiovascular protection3.

    4. Alpha-Ketoglutarate (AKG):

      • AKG, a key molecule in the energy production pathway, has been suggested to extend lifespan and reduce biological age markers in preliminary studies. Supplementing with AKG may benefit metabolic health and reduce aging-related cellular damage4.

    5. Lithium:

      • Often used pharmacologically for bipolar disorder, low-dose lithium supplementation has been associated with increased longevity in observational studies. It is thought to exert neuroprotective and anti-inflammatory effects, contributing to decreased mortality5.

    These supplements have shown promise in various studies, but always consult a healthcare provider before starting any new supplement regimen.

    Footnotes

    1. Christopher Shade, "The Science Behind NMN–A Stable, Reliable NAD+Activator and Anti-Aging Molecule," PubMed Central, 2021. ↩

    2. Andrei Biţă, "Nicotinamide Riboside, a Promising Vitamin B3 Derivative for Healthy Aging and Longevity: Current Research and Perspectives," PubMed Central, 2023. ↩

    3. Dan-Dan Zhou, "Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases," PubMed Central, 2021. ↩

    4. Oleksandr Demidenko, "Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins," PubMed Central, 2021. ↩

    5. Elisa Araldi, "Lithium treatment extends human lifespan: findings from the UK Biobank," PubMed, 2023. ↩

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