Rapamycin is an intriguing compound often discussed in the context of aging and longevity. It is known to extend lifespan in animal models, particularly mice, and delay some age-related diseases¹². However, its use poses several challenges and potential risks, especially in humans.

Benefits:

• Longevity: Rapamycin has been shown to extend both mean and maximum lifespan in mice, even when administered later in life³. It works by inhibiting the mammalian target of rapamycin (mTOR), which plays a crucial role in cellular growth and metabolism¹.

• Delaying Age-Related Pathologies: The compound has demonstrated the capability to slow the progression of age-associated conditions in animal models².

Risks:

• Side Effects: Rapamycin may increase risks for diabetes, cardiovascular issues, and causes skin, hair, and nail problems⁴. These side effects might overshadow its potential anti-aging benefits in humans.

• Complex Effects on the Immune System: As an immunosuppressant, rapamycin can have complex impacts on immune function⁴.

Uncertainties:

• Human Applications: While the results in animal studies are promising, translating these findings to human applications remains uncertain. The optimal dose and timing for effective supplementation without side effects have not been established¹.

Given the potential benefits and uncertainties, it is crucial to consult healthcare professionals before considering rapamycin supplementation. They can provide personalized guidance based on current research and individual health conditions.

Footnotes

1. Matt Kaeberlein, "Rapamycin and aging: When, for how long, and how much?" PubMed Central. ↩ ↩² ↩³

2. Lan Ye, "Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance," PubMed Central. ↩ ↩²

3. Ramasamy Selvarani, "Effect of rapamycin on aging and age-related diseases—past and future," PubMed Central. ↩

4. Lan Ye, "Rapamycin and aging: When, for how long, and how much?" PubMed Central. ↩ ↩²