Exploring Supplements: Magnesium Glycinate, Spermidine, and NMN for Longevity
A 22-year-old with OCD considers using Magnesium Glycinate, Spermidine, and NMN supplements for longevity. Discusses benefits, side effects, and the importance of consulting healthcare professionals before starting a supplement regimen, especially with pre-existing conditions.
Should I (22M) supplement? Magnesium Glycinate, Spermidine and NMN Longevity
For context I am a 22M living in a tropical country with diagnosed OCD. I am looking to invest in NMN, Magnesium Glycinate and Spermidine for longevity, but have been hesitant due to some contradiction on long term side effects. Should I (relatively young) be supplementing, and will it impact me negatively in the long run?
Here's a breakdown of the potential benefits and side effects of the supplements you mentioned:
Magnesium Glycinate
- Benefits: Magnesium is essential for various bodily functions, including nerve and muscle function, blood sugar regulation, and inflammatory control1. Magnesium glycinate, specifically, is well-regarded for its ability to minimize gastrointestinal discomfort compared to other forms of magnesium2. It has been linked to improvements in mood and anxiety, which may be particularly relevant for conditions such as OCD3.
- Side Effects: Generally well tolerated, though high doses could lead to diarrhea, nausea, or more severe effects if kidney function is compromised2.
Spermidine
- Benefits: Spermidine has been studied for its potential anti-aging effects and roles in cardiovascular and neurological health4. It acts as an autophagy inducer which helps in the removal of dysfunctional cells, potentially slowing aging processes4.
- Side Effects: Current research suggests that spermidine is safe, but more studies are needed to completely understand long-term effects4.
NMN (Nicotinamide Mononucleotide)
- Benefits: NMN is a precursor to NAD+, which is essential for energy metabolism, DNA repair, and cellular processes involved in aging56. Studies in mice show that NMN can increase activity levels, reduce frailty, and improve metabolic health56. Its effects on humans, although promising, still require more comprehensive studies6.
- Side Effects: No significant adverse effects have been noted at normal supplementation levels in both mice and short-term human studies56.
Before starting any new supplement regimen, especially with an existing condition like OCD, it's important to consult with a healthcare professional. They can offer personalized advice and monitor any potential interactions with your existing treatment or conditions.
Footnotes
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Magnesium glycinate: Is this supplement helpful for you? - Mayo Clinic Press ↩
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Magnesium glycinate: Is this supplement helpful for you? - Mayo Clinic Press ↩ ↩2
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Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomized controlled trial ↩
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A comprehensive review of spermidine: Safety, health effects, absorption and metabolism, food materials evaluation, physical and chemical processing, and bioprocessing - PubMed ↩ ↩2 ↩3
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Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner ↩ ↩2 ↩3
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The Science Behind NMN–A Stable, Reliable NAD+Activator and Anti-Aging Molecule ↩ ↩2 ↩3 ↩4