Spermidine is a naturally occurring polyamine that has been shown to have important anti-aging and health-promoting properties. It is found in various foods and supplements and has been studied extensively for its potential benefits in extending lifespan, preventing age-related diseases, and promoting autophagy, a process critical for cellular renewal and maintenance.

Key Points About Spermidine:

1. Longevity and Healthspan:

   • Spermidine supplementation has been demonstrated to extend lifespan in multiple model organisms, including yeast, nematodes, flies, and mice¹.
   • In humans, higher dietary intake of spermidine is associated with reduced overall, cardiovascular, and cancer-related mortality¹.

2. Mechanisms of Action:

   • Spermidine acts as an inhibitor of acetyl transferase EP300, which leads to the stimulation of autophagy¹. Autophagy is essential for cellular homeostasis and longevity.
   • By enhancing autophagy, spermidine helps in the removal of damaged cellular components, thereby promoting cellular health and longevity¹.

3. Cognitive Enhancement:

   • A randomized clinical trial indicated that spermidine supplementation may improve cognitive functions in older adults with subjective cognitive decline².

4. Anti-inflammatory Effects:

   • Spermidine has been shown to protect against liver damage by reducing oxidative stress and improving mitochondrial function³.
   • It also ameliorates colitis by inducing anti-inflammatory macrophages and preventing intestinal dysbiosis⁴.

5. Safety and Pharmacokinetics:

   • Studies suggest that spermidine supplementation is safe, with no adverse effects observed in toxicity studies⁵.
   • High-dose spermidine supplementation does not necessarily increase spermidine levels in blood plasma, indicating that it may be converted presystemically to other bioactive compounds like spermine⁶.

Conclusion

Spermidine offers promising benefits for aging and age-related diseases, primarily through its role in stimulating autophagy and reducing inflammation. It is considered safe for use, as evidenced by various studies. However, further clinical studies are needed to fully understand its benefits and optimal dosage in humans.

If you are interested in purchasing supplements containing spermidine, please let me know, and I can help you search for products.

Footnotes

1. Spermidine delays aging in humans ↩ ↩² ↩³ ↩⁴

2. Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults ↩

3. Spermidine Supplementation Protects the Liver Endothelium from Liver Damage in Mice ↩

4. Spermidine Ameliorates Colitis via Induction of Anti-Inflammatory Macrophages and Prevention of Intestinal Dysbiosis ↩

5. A toxicological assessment of spermidine trihydrochloride ↩

6. High-Dose Spermidine Supplementation Does Not Increase Spermidine Levels in Blood Plasma ↩

Genius Pre Supplement

Genius Pre is a pre-workout supplement designed to enhance physical performance, energy, and mental focus. It typically includes a blend of ingredients aimed at supporting various aspects of exercise and cognitive function:

1. Caffeine: Often included for its stimulant effects, caffeine helps improve energy levels, alertness, and physical performance. However, long-term effects and its impact on heart health should be considered¹.

2. Creatine Monohydrate: Widely recognized for its role in enhancing muscle strength, endurance, and overall exercise performance². Creatine also shows promise in cognitive enhancements and neuroprotective effects³.

3. Beta-Alanine: Known to increase muscle endurance and reduce fatigue during high-intensity exercises⁴.

4. Amino Acids: These building blocks of protein help in muscle repair and growth, reducing muscle soreness and promoting recovery⁵.

5. Nitric Oxide Precursors: These compounds, like L-arginine and L-citrulline, are commonly included to improve blood flow and muscle "pump" during workouts⁶.

Potential Benefits:

• Enhanced Physical Performance: The combination of creatine and beta-alanine is particularly effective in boosting muscle strength and endurance²⁴.
• Increased Energy and Focus: Caffeine and various amino acids contribute to heightened alertness and reduced perception of effort¹.
• Improved Recovery: Amino acids and creatine help in faster muscle recovery and reduced soreness post-exercise⁵.

Possible Side Effects:

• Cardiovascular Concerns: Excessive caffeine intake can lead to cardiovascular issues such as increased heart rate and blood pressure¹.
• Digestive Issues: Some users report gastrointestinal discomfort from ingredients like beta-alanine⁴.
• Skin Reactions: High doses of niacin, commonly found in pre-workout supplements, can cause skin flushing and irritation⁶.

Summary:

Genius Pre provides a robust blend of ingredients aimed at enhancing both physical and mental performance during workouts. While it offers numerous benefits, users should be mindful of the potential side effects and consider personal tolerance levels for ingredients like caffeine. Consulting with a healthcare professional before starting any new supplement regimen is always advisable.

Would you like to search for specific products containing these key ingredients?

Footnotes

1. Miguel A Rodriguez Guerra, "Pre-workout Induced Demand Ischemia," PMC, 2023. ↩ ↩² ↩³

2. Patricia J. Allen, "Creatine metabolism and psychiatric disorders," PMC, 2024. ↩ ↩²

3. Scott C. Forbes, "Effects of Creatine Supplementation on Brain Function and Health," PMC, 2022. ↩

4. Andrew R. Jagim, "Common Habits, Adverse Events, and Opinions Regarding Pre-Workout Supplement Use," PMC, 2019. ↩ ↩² ↩³

5. Nari Ahn, "Effects of creatine monohydrate supplementation and exercise on depression-like behaviors,” PMC, 2016. ↩ ↩²

6. Amer Abdulrahman Almaiman, "Effect of testosterone boosters on body functions," PMC. ↩ ↩²