The Potential Benefits and Safety of Nicotinamide Mononucleotide (NMN) Supplementation
Explore how NMN supplements can elevate NAD+ levels, enhance physical performance, support metabolic health, offer anti-aging benefits, and improve cognitive functions. Learn about current research findings and safety considerations for this promising supplement.
NMN
Nicotinamide mononucleotide (NMN) is a popular supplement that has gained attention for its potential anti-aging benefits and its role in boosting levels of nicotinamide adenine dinucleotide (NAD+), a critical coenzyme in various physiological processes.
Here are some key findings related to NMN supplementation:
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Increases NAD+ Levels:
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Improves Physical Performance:
- Clinical trials in middle-aged adults have demonstrated that NMN supplementation can significantly improve physical performance. For instance, participants who took NMN showed better results in the six-minute walking test compared to those who took a placebo4.
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Supports Metabolic Health:
- NMN appears to enhance insulin sensitivity and improve markers of cardiovascular health. However, more specific effects on metabolic parameters like HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) have shown mixed results and require further investigation4.
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Potential Anti-Aging Benefits:
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Enhances Cognitive and Neuromuscular Functions:
- Research on NMN's impact on cognitive functions and neuromuscular junctions (NMJs) in conditions like ALS (Amyotrophic Lateral Sclerosis) suggests potential benefits. NMN supplementation improved motor function and neuron health in mouse models6.
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Safety and Tolerability:
While the emerging evidence is promising, more extensive and long-term human trials are needed to fully establish the benefits and safety of NMN supplementation.
Footnotes
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Lin Yi, "The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults," PMC, 2022. ↩
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Masaki Igarashi, "Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels," PMC, 2022. ↩
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Lin Yi, "The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults," PMC, 2022. ↩ ↩2 ↩3 ↩4
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Harshani Nadeeshani, "Nicotinamide mononucleotide (NMN) as an anti-aging health product," PMC, 2021. ↩
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Samuel Lundt, "NMN supplementation enhances motor and NMJ function in ALS," PubMed, 2022. ↩
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Lin Yi, "The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults," PMC, 2022. ↩
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