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Exploring Spermidine: Anti-Aging, Cognitive, and Cardiovascular Benefits

Discussing the health benefits of spermidine, including its role in anti-aging, cognitive improvement, cardiovascular protection, and its dietary sources and supplementation safety.


  • Spermidine

  • Spermidine is a naturally occurring polyamine found in all living cells, known for its multiple health benefits, particularly related to aging and autophagy. Here are some key findings from recent studies on spermidine:

    Health Benefits of Spermidine

    1. Anti-Aging:

      • Spermidine helps extend lifespan and improve health span by inducing autophagy, a cellular process that removes damaged components12.
      • It has been shown to extend lifespan in various model organisms including yeast, nematodes, flies, and mice3.
    2. Cognitive Health:

      • Studies indicate that spermidine supplementation can improve memory performance and cognitive function, particularly in older adults45.
      • It has shown potential in delaying neurodegenerative diseases like Alzheimer’s by reducing oxidative stress and enhancing autophagy6.
    3. Cardiovascular Protection:

      • Spermidine has cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function. It also correlates with reduced blood pressure and lower incidence of cardiovascular diseases78.
    4. Anti-Inflammatory and Antioxidant Properties:

      • It reduces inflammation and oxidative stress, both of which are linked to aging and various chronic diseases910.
    5. Cancer Protection:

      • Spermidine exhibits anti-tumor properties and may enhance the body's anti-tumor immunosurveillance11.

    Dietary Sources of Spermidine

    Spermidine is abundant in certain foods, notably in:

    • Fresh peppers
    • Wheat germ
    • Broccoli
    • Cauliflower
    • Cheeses
    • Soy products like natto and shiitake mushrooms12.

    Supplementation and Safety

    • Long-term spermidine supplementation (1.2 mg/day) has been found safe and well-tolerated in elderly individuals13.
    • Supplementation increases blood polyamine levels, which decline with age14.

    Conclusion

    Spermidine holds great promise as a supplement for enhancing longevity, cognitive function, and cardiovascular health through its role in promoting autophagy and reducing inflammation. Regular intake through diet or supplements can help counteract the age-related decline in spermidine levels.

    Footnotes

    1. Madeo, F. (2018). Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans? PMC

    2. Zou, D. (2022). A comprehensive review of spermidine. PubMed

    3. Madeo, F. (2018). Spermidine delays aging in humans. PMC

    4. Schwarz, C. (2022). Effects of Spermidine Supplementation on Cognition in Older Adults. PubMed

    5. Liu, J.-K. (2022). Antiaging agents. PMC

    6. Lumkwana, D. (2022). Investigating the Role of Spermidine in Alzheimer's. PMC

    7. Eisenberg, T. (2024). Cardioprotection and lifespan extension by spermidine. PMC

    8. Liu, J.-K. (2022). Antiaging agents. PMC

    9. Filfan, M. (2020). Long-term treatment with spermidine increases health span in rats. PMC

    10. Đorđievski, S. (2023). Spermidine dietary supplementation in bees. PMC

    11. Madeo, F. (2018). Spermidine delays aging in humans. PMC

    12. Liu, J.-K. (2022). Antiaging agents. PMC

    13. Schwarz, C. (2022). Effects of Spermidine Supplementation on Cognition in Older Adults. PubMed

    14. Lumkwana, D. (2022). Investigating the Role of Spermidine in Alzheimer's. PMC

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