Exploring Spermidine: Anti-Aging, Cognitive, and Cardiovascular Benefits
Discussing the health benefits of spermidine, including its role in anti-aging, cognitive improvement, cardiovascular protection, and its dietary sources and supplementation safety.
Spermidine
Spermidine is a naturally occurring polyamine found in all living cells, known for its multiple health benefits, particularly related to aging and autophagy. Here are some key findings from recent studies on spermidine:
Health Benefits of Spermidine
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Anti-Aging:
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Cognitive Health:
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Cardiovascular Protection:
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Anti-Inflammatory and Antioxidant Properties:
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Cancer Protection:
- Spermidine exhibits anti-tumor properties and may enhance the body's anti-tumor immunosurveillance11.
Dietary Sources of Spermidine
Spermidine is abundant in certain foods, notably in:
- Fresh peppers
- Wheat germ
- Broccoli
- Cauliflower
- Cheeses
- Soy products like natto and shiitake mushrooms12.
Supplementation and Safety
- Long-term spermidine supplementation (1.2 mg/day) has been found safe and well-tolerated in elderly individuals13.
- Supplementation increases blood polyamine levels, which decline with age14.
Conclusion
Spermidine holds great promise as a supplement for enhancing longevity, cognitive function, and cardiovascular health through its role in promoting autophagy and reducing inflammation. Regular intake through diet or supplements can help counteract the age-related decline in spermidine levels.
Footnotes
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Madeo, F. (2018). Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans? PMC ↩
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Zou, D. (2022). A comprehensive review of spermidine. PubMed ↩
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Schwarz, C. (2022). Effects of Spermidine Supplementation on Cognition in Older Adults. PubMed ↩
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Lumkwana, D. (2022). Investigating the Role of Spermidine in Alzheimer's. PMC ↩
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Eisenberg, T. (2024). Cardioprotection and lifespan extension by spermidine. PMC ↩
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Filfan, M. (2020). Long-term treatment with spermidine increases health span in rats. PMC ↩
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Đorđievski, S. (2023). Spermidine dietary supplementation in bees. PMC ↩
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Schwarz, C. (2022). Effects of Spermidine Supplementation on Cognition in Older Adults. PubMed ↩
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Lumkwana, D. (2022). Investigating the Role of Spermidine in Alzheimer's. PMC ↩
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