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Medicinal Mushrooms Enhancing Th1 Immunity: Key Varieties and Benefits

Explore the immune-boosting properties of various medicinal mushrooms such as Agaricus blazei, Oyster mushroom, Turkey Tail, Lion’s Mane, and Reishi. These mushrooms are known to raise Th1 immunity and offer additional health benefits including antiviral and anti-inflammatory effects.

  • medicinal mushrooms that raise strictly Th1 immunity ?

  • Several medicinal mushrooms have been identified to enhance Th1 immunity, which is crucial for cellular immune responses against intracellular pathogens like viruses and certain bacteria. Here are some primary examples:

    1. Agaricus blazei Murill (AbM):

      • Agaricus blazei M contains immunomodulating polysaccharides such as β-glucans, which have been shown to stimulate innate immune cells including monocytes, NK cells, and dendritic cells. This mushroom has demonstrated the ability to modulate Th1/Th2 balance, promoting Th1 cytokines such as IFN-γ12.

    2. Pleurotus cornucopiae (Oyster mushroom):

      • Oyster mushroom extract has been shown in a clinical trial to elevate levels of Th1 cytokines like IFN-γ and IL-12 while minimally affecting Th2-related cytokines. This suggests a specific enhancement of the Th1-phenotype immune response3.

    3. Trametes versicolor (Turkey Tail):

      • This mushroom has immunomodulatory effects, with specific extracts shown to influence the immune response by increasing the production of Th1 cytokines, contributing to the activation of cellular immunity[^4].

    4. Hericium erinaceus (Lion’s Mane):

      • Known for its neuroprotective properties, this mushroom also exhibits immunomodulatory effects that can help shift the immune response towards a Th1 phenotype via the stimulation of macrophages and other immune cells[^5].

    5. Ganoderma lucidum (Reishi):

      • Reishi contains bioactive molecules that can boost Th1 immune responses. It has been used traditionally to enhance immune function, including increasing the activity of NK cells and the production of Th1 cytokines[^6].

    These mushrooms not only boost the Th1 immune response but also have a range of other health benefits, including antiviral, antitumor, and anti-inflammatory properties.

    Footnotes

    1. Geir Hetland, "The Mushroom Agaricus blazei Murill Elicits Medicinal Effects on Tumor, Infection, Allergy, and Inflammation through Its Modulation of Innate Immunity and Amelioration of Th1/Th2 Imbalance and Inflammation," PubMed, 2011. ↩

    2. A. Ganeshpurkar, "Medicinal mushrooms: Towards a new horizon," PMC, 2023. ↩

    3. [Aiko Tanaka, "Enhancement of the Th1-phenotype immune system by the intake of Oyster mushroom (Tamogitake) extract in a double-blind, placebo-controlled study," PMC, 201 ↩

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