Based on recent studies, several supplements show promise in addressing fear and increasing motivation. Here are some of the most noteworthy ones:

1. Vitamin B6: High doses of Vitamin B6 have been found to significantly reduce anxiety. This effect is believed to be due to Vitamin B6's role in increasing the production of gamma-aminobutyric acid (GABA), a neurotransmitter that has calming effects on the nervous system¹.

2. Ashwagandha: This herb is well-known for its anxiolytic and stress-relieving properties. Ashwagandha helps reduce cortisol levels, which can alleviate feelings of stress and anxiety².

3. Alpha-Glycerylphosphorylcholine (αGPC): This supplement has been shown to increase motivation in healthy individuals by enhancing cholinergic function and monoaminergic transmission, including dopaminergic and serotonergic systems³.

4. Vitamin C: Supplementation with Vitamin C has been associated with increased attention and work engagement. It's believed to improve mental vitality and cognitive performance requiring sustained attention⁴.

5. Flavones from Erythrina falcata: These compounds have shown potential in modulating fear memory, which could be relevant for conditions involving excessive fear responses⁵.

These supplements may be beneficial for reducing fear and enhancing motivation, but it is always advisable to consult a healthcare professional before starting any new supplement regimen.

Footnotes

1. Vitamin B6: A new approach to lowering anxiety, and depression? ↩

2. Mayo Clinic - Can ashwagandha supplements help with stress and anxiety relief? ↩

3. Alpha-Glycerylphosphorylcholine Increases Motivation in Healthy Volunteers ↩

4. Vitamin C supplementation promotes mental vitality in healthy young adults ↩

5. Flavones from Erythrina falcata are modulators of fear memory ↩