Shilajit is a herbal-mineral substance renowned for its potential health benefits. Research indicates several specific advantages for women:

1. Bone Health: A study revealed that shilajit can reduce oxidative stress, inflammation, and bone loss in postmenopausal women with osteopenia. It helps preserve bone mineral density in a dose-dependent manner¹.

2. Skin Health: Another research demonstrated that shilajit supplementation in middle-aged women can promote the induction of microvascular and extracellular matrix mechanisms. This affects the skin positively, potentially enhancing its appearance and health².

3. Overall Well-being: Shilajit is generally known for its adaptogenic properties, which help reduce fatigue and enhance overall energy levels. It also possesses antioxidant properties that can support various bodily functions, including boosting immune health and reducing overall oxidative stress.

Footnotes

1. Usharani Pingali, "Shilajit extract reduces oxidative stress, inflammation, and bone loss to dose-dependently preserve bone mineral density in postmenopausal women with osteopenia: A randomized, double-blind, placebo-controlled trial," PubMed, 2022. ↩

2. Amitava Das, "Skin Transcriptome of Middle-Aged Women Supplemented With Natural Herbo-mineral Shilajit Shows Induction of Microvascular and Extracellular Matrix Mechanisms," NCBI, 2024. ↩

Lithium orotate is a compound that combines lithium and orotic acid. It is often marketed as a dietary supplement and is considered a low-dose form of lithium. Here are some of its potential benefits and key points:

1. Mental Health: Lithium is widely recognized for its mood-stabilizing properties, particularly in the treatment of bipolar disorder¹. However, lithium orotate is preferred by some because it can cross the blood-brain barrier more efficiently, allowing for lower doses compared to lithium carbonate, with fewer side effects².

2. Neuroprotective Effects: Low-dose lithium has been associated with neuroprotective benefits, including potential positive effects on cognitive function and reducing the risk of neurodegenerative diseases such as Alzheimer's³.

3. Anti-aging and Longevity: Studies indicate that lithium supplementation can extend lifespan and improve health parameters in various model organisms. Its use is correlated with decreased mortality rates in humans, particularly those with affective disorders⁴.

4. Bone and Muscle Health: Low-dose lithium can promote bone formation and muscle repair by inhibiting GSK3 activity, which enhances the Wnt signaling pathway. This mechanism is beneficial for conditions such as osteoporosis and sarcopenia³.

5. Metabolic Benefits: Lithium helps in regulating glucose levels and reducing oxidative stress in the pancreas, which may benefit individuals with metabolic disorders like obesity and type 2 diabetes³.

6. Safety Profile: Lithium orotate has been studied for its toxicity and safety. It was found to be non-mutagenic and non-toxic in various tests, supporting its safety at recommended doses⁵.

Additional Information

• Dosage: The effective dose of lithium orotate is generally much lower than that of prescription lithium carbonate. Studies have indicated significant clinical effects at doses as low as 5 mg daily².
• Availability: Lithium orotate is available as a supplement and does not require a prescription, unlike lithium carbonate².

References

Footnotes

1. Robert M Post, "The New News about Lithium: An Underutilized Treatment in the United States," PMC, 2017. ↩

2. Shaheen E Lakhan, "Nutritional therapies for mental disorders," PMC, 2021. ↩ ↩² ↩³

3. Sophie I Hamstra, "Beyond its Psychiatric Use: The Benefits of Low-dose Lithium Supplementation," PubMed, 2021. ↩ ↩² ↩³

4. Elisa Araldi, "Lithium treatment extends human lifespan: findings from the UK Biobank," PMC, 2023. ↩

5. Timothy S Murbach, "A toxicological evaluation of lithium orotate," PubMed, 2021. ↩