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Managing L-Glutamine Dosage: Tips for Reducing Anxiety and Side Effects

This conversation explores the experience of starting L-glutamine supplementation, highlighting the importance of beginning with a low dose to mitigate negative effects, such as anxiety. It also discusses personal tolerance levels and the necessity of consulting with a healthcare provider.


  • L-glutamine
    Did people find they had to start slowly with this and titrate up? Did this mitigate any negative effects?

    I tried l-glutamine a while ago but I did take 5g straight away which led to some anxiety which I thought meant I couldn’t tolerate it at all but I’m thinking now perhaps I started too quickly

  • Starting with a lower dose of L-glutamine and gradually increasing it can help mitigate potential negative effects, such as anxiety, which some individuals experience1. L-glutamine can cause side effects, including abdominal pain, headache, and nausea2. If these symptoms occur, adjusting the dosage or stopping the supplementation might be necessary.

    For many, starting with a small dose and observing the body's response can be an effective way to determine personal tolerance levels. It's generally advisable to consult with a healthcare provider before making changes to the dosage, especially if there were adverse reactions previously.

    Footnotes

    1. MedlinePlus Drug Information on L-glutamine

    2. Michael Gleeson, "Dosing and efficacy of glutamine supplementation in human exercise and sport training," PubMed

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