Considering the combination of various supplements can sometimes lead to interactions that might enhance or mitigate their individual effects. Here are some key points based on authoritative sources:

1. Vitamin D3 + K2: These are commonly combined to support bone health. K2 ensures that calcium transported by Vitamin D is absorbed by your bones where it's needed, rather than accumulating in your arteries¹.

2. Ashwagandha: Known for reducing stress and anxiety. It doesn't have significant interactions with many supplements, but it's advisable to avoid combining with sedatives due to potential additive effects².

3. Theanine: Often used for its calming effects. It can be taken safely with most supplements and is commonly combined with caffeine to balance the stimulant's effects³.

4. Lion's Mane: This can enhance cognitive function and is generally safe to take with other nootropics and adaptogens like ashwagandha and theanine⁴.

5. Move Free (Glucosamine and Chondroitin): These are used for joint health and can be taken alongside most other supplements without known adverse interactions⁵.

6. Magenhance (Magnesium): Magnesium can help with stress, muscle function, and sleep. However, it should be taken cautiously with other minerals to avoid imbalances⁶.

7. Iron Fumarate and Folate: Iron supplements can interfere with the absorption of other minerals like zinc and calcium. Folate is often combined with other B vitamins⁷.

8. Phenylalanine: It's an amino acid that can affect neurotransmitter levels and should be taken cautiously with other supplements that impact mood and cognition⁸.

9. Probiotics: Generally safe and beneficial for gut health; they can be combined with most other supplements⁹.

10. Choline and Inositol: These work well together for cognitive support and are safe to take with many other supplements¹⁰.

11. Cranberry and Hibiscus: Often used for urinary health, these can typically be combined with other herbal supplements¹¹.

12. Lysine: An essential amino acid that's safe with most other supplements¹².

13. SAM-e: Used primarily for mood support, should be taken cautiously with other mood-altering supplements¹³.

14. Pregnenolone: A precursor to various hormones and should be taken cautiously due to its widespread effects on hormone levels¹⁴.

15. Chlorophyll: Typically safe, often taken for its detoxifying properties¹⁵.

16. 5-HTP: This impacts serotonin levels, and caution should be taken if combined with other serotonin-influencing substances¹⁶.

17. Evening Primrose Oil: Usually safe, often used for skin and hormonal health¹⁷.

18. Potassium Gluconate: Necessary for maintaining potassium levels, but care should be taken if combined with other electrolytes¹⁸.

Combining these supplements should be done cautiously, especially those that affect the same physiological systems, such as mood (ashwagandha, theanine, phenylalanine, 5-HTP, SAM-e), hormones (pregnenolone, SAM-e), and mineral balance (magnesium, iron, potassium).

Footnotes

1. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density. ↩

2. Mayo Clinic on Ashwagandha. ↩

3. Effect of a combination of Magnesium, B Vitamins, Rhodiola, and Green Tea (L-Theanine) on chronically stressed individuals. ↩

4. Mayo Clinic on Lion's Mane. ↩

5. Mayo Clinic on Glucosamine. ↩

6. Magnesium, B Vitamins, and Stress. ↩

7. Iron and Folate supplementation. ↩

8. Mayo Clinic on Amino Acids. ↩

9. Probiotics Health Information. ↩

10. Choline and Inositol Information. ↩

11. Cranberry and Hibiscus. ↩

12. Mayo Clinic on Lysine. ↩

13. SAM-e Clinical Trials. ↩

14. Pregnenolone Supplement Information. ↩

15. Chlorophyll Information. ↩

16. 5-HTP and Serotonin. ↩

17. Evening Primrose Oil Information. ↩

18. Potassium Gluconate Supplement Information. ↩