Does Lactobacillus rhamnosus Help Lower Blood Sugar?

Based on research available in Pillser's database, there is some limited evidence suggesting Lactobacillus rhamnosus (a probiotic) may have a beneficial effect on glycemic control.

What the Research Says

Pillser's database contains 1 study examining Lactobacillus rhamnosus in relation to improved glycemic control¹:

Effect Type	Count
Beneficial	1
Neutral	0
Harmful	0

The study (a 2023 animal study on diabetic mice) found that a mixture of Lactobacillaceae (which included Lactobacillus strains) was able to:

• Lower fasting blood glucose (FBG)
• Reduce inflammation
• Reduce liver, kidney, and pancreas damage
• Promote the PI3K/AKT signaling pathway (a pathway involved in insulin signaling)²

Important Caveats

1. Animal study: This research was conducted in db/db mice, not humans. Results in animal models don't always translate directly to human outcomes.
2. Mixed strains: The study used a mixture of Lactobacillaceae strains, not Lactobacillus rhamnosus alone, so the specific contribution of this single strain is unclear.
3. Limited evidence: With only 1 study available, the evidence base is very small.

Bottom Line

Early research suggests Lactobacillus rhamnosus may have potential for supporting blood sugar regulation, but human clinical trials are needed before firm conclusions can be drawn. If you're looking to support healthy blood sugar levels, it's best to consider a comprehensive approach including diet, exercise, and consultation with a healthcare professional.

Footnotes

1. Pillser research database, Lactobacillus rhamnosus and Improved Glycemic Control. ↩

2. "Screening of Potential Probiotic Lactobacillaceae and Their Improvement of Type 2 Diabetes Mellitus by Promoting PI3K/AKT Signaling Pathway in db/db Mice," Pillser, 2023. ↩