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Exploring GW501516: Benefits, Risks, and Regulatory Status of Cardarine

Dive into an in-depth discussion on GW501516, also known as Cardarine. Learn about its metabolic and performance benefits, health implications, regulatory status, and the risks associated with its misuse.


  • gw501516

  • GW501516, also known as Cardarine or Endurobol, is a peroxisome proliferator-activated receptor delta (PPAR-δ) agonist extensively researched for its effects on fat burning, muscle production, endurance enhancement, and potential therapeutic applications. Here are some key points based on research findings:

    1. Metabolic and Performance Benefits:

      • GW501516 promotes the change from glucose to lipid utilization in the body, increasing fat-burning capacity and muscle production1.
      • It's often abused for performance enhancement among athletes, despite being prohibited by the World Anti-Doping Agency (WADA) since 20091.
    2. Health Implications:

      • Although it has shown positive effects on reducing inflammation and improving insulin sensitivity, particularly in high-fructose diet-induced metabolic disturbances2, its development as a therapeutic drug was halted due to its tumorigenic effects observed in clinical trials3.
      • Studies suggest anti-cancer properties in certain models, inhibiting cell proliferation and promoting apoptosis in nasopharyngeal carcinoma cells4.
    3. Regulatory Status and Risks:

      • It is categorized under prohibited substances by WADA due to its potential for misuse and associated health risks1.
      • Clinical reports indicate severe health issues, such as liver damage and rhabdomyolysis, among individuals abusing GW5015165.
    4. Research and Clinical Trials:

      • Research on rodents shows the drug can improve markers of liver health and reduce inflammation2.
      • Despite these benefits, safety concerns have led to its prohibition and caution among the scientific community3.

    Footnotes

    1. Pascal Kintz, "Testing for GW501516 (cardarine) in human hair using LC/MS-MS and confirmation by LC/HRMS," PubMed 2 3

    2. D’Angelo C Magliano, "Short-term administration of GW501516 improves inflammatory state in white adipose tissue and liver damage in high-fructose-fed mice," PubMed 2

    3. Martin Weihrauch, "Pharmacological targeting of exercise adaptations in skeletal muscle," NCBI 2

    4. Yangyang Ji, "PPARβ/δ Agonist GW501516 Inhibits Tumorigenicity of Undifferentiated Nasopharyngeal Carcinoma," NCBI

    5. Pascal Kintz, "Peroxisome Proliferator-Activated Receptor Delta Agonist (PPAR- δ) and Selective Androgen Receptor Modulator (SARM) Abuse," NCBI

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