When aiming to gain lean muscle weight, certain supplements have shown consistent evidence in promoting muscle hypertrophy and strength gains. Here are some of the most effective supplements based on current research:

1. Creatine: Consistently shown to increase muscle mass and strength when combined with resistance training[^1^][^2^]. It enhances regional skeletal muscle hypertrophy, especially in younger adults, and can lead to significant increases in whole-body lean mass.

2. Protein Supplements: Protein is vital for muscle growth, and supplementation can help accelerate gains in muscle mass and strength. Whey protein is particularly effective when consumed immediately before and after resistance exercise[^3^][^4^]. Studies have shown significant improvements in muscle mass and strength with regular protein supplementation.

3. Branched-Chain Amino Acids (BCAAs): There is mixed evidence, but BCAAs may help reduce muscle soreness and promote muscle growth when consumed around workout times[^1^].

4. Beta-Alanine: This amino acid can enhance exercise performance by reducing muscle fatigue, which may indirectly support muscle growth through more intense training sessions[^1^].

5. Omega-3 Fatty Acids: Polyunsaturated fatty acids like EPA and DHA have been shown to support muscle protein synthesis and preserve muscle mass, particularly in older adults[^1^][^5^].

It's important to note that while some supplements can help, they work best when combined with a proper diet and regular resistance training.