There are several supplements that have been shown to potentially help with knee pain, particularly related to osteoarthritis. Here are some of the key supplements and the reasoning behind their use:

1. Glucosamine and Chondroitin: These are naturally occurring substances in the cartilage. Supplements containing glucosamine sulfate and chondroitin sulfate can help manage pain, although they do not seem to help the joint grow new cartilage or prevent arthritis from worsening¹.

2. Collagen: Collagen supplements may improve symptoms of osteoarthritis by promoting cartilage health².

3. Methylsulfonylmethane (MSM): MSM may reduce inflammation and pain associated with osteoarthritis².

4. Curcumin (from Turmeric): Curcumin has anti-inflammatory properties and can be effective in reducing knee pain and improving function³.

5. Hyaluronic Acid: This is found naturally in joint fluid and can help with lubrication. Supplementation can potentially alleviate symptoms¹.

6. S-Adenosyl-L-Methionine (SAMe): It is claimed to help arthritis, although evidence is not robust¹.

7. Antioxidants: Supplements based on curcumin and avocado-soya bean unsaponifiables have shown benefits in pain relief and function³. Other antioxidants may have varied effects, so more research is needed.

8. Boswellia Serrata: This herb is used in Ayurvedic medicine and may help reduce inflammation and pain³.

Before starting any supplement, it is important to discuss with a healthcare provider to ensure safety and avoid potential interactions with other medications.

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Footnotes

1. MedlinePlus Medical Encyclopedia: Medicines, injections, and supplements for arthritis ↩ ↩² ↩³

2. Nutraceutical Approach to Chronic Osteoarthritis: From Molecular Research to Clinical Evidence ↩ ↩²

3. Benefits of antioxidant supplements for knee osteoarthritis: rationale and reality ↩ ↩² ↩³