For chronic musculoskeletal issues, including radiculopathy in the cervical and lumbar spine accompanied by muscle pain and tension, there are several evidence-based supplements that may be beneficial:

1. Vitamin D: Research suggests that correcting vitamin D deficiency can significantly improve chronic neck and back pain, as well as muscle spasms¹². In a case series, patients with chronic pain had more than a 70% improvement in symptoms after taking 50,000 IU of vitamin D once a week for 12 weeks¹.

2. Glucosamine and Chondroitin Sulfate: These supplements are commonly used for osteoarthritis but have also shown promise in treating symptomatic spinal disc degeneration. In a case report, oral intake of glucosamine and chondroitin sulfate for two years was associated with disk recovery, as seen through MRI signals³⁴.

3. Nutritional Supplements for Neuropathic Pain: Supplements like alpha-lipoic acid, acetyl-L-carnitine, and omega-3 fatty acids have been studied for their benefits in managing neuropathic pain, which includes radicular pain⁵.

Before starting any new supplement regimen, it is advisable to consult with a healthcare professional to ensure these supplements are appropriate for your specific condition and do not interact with other medications you may be taking.

Footnotes

1. Chunbo Cai, "Treating Vitamin D Deficiency and Insufficiency in Chronic Neck and Back Pain and Muscle Spasm: A Case Series," PMC, 2019. ↩ ↩²

2. Mahsa Sedighi, "Role of vitamin D3 in Treatment of Lumbar Disc Herniation—Pain and Sensory Aspects: Study Protocol for a Randomized Controlled Trial," PMC, 2025. ↩

3. Wim J van Blitterswijk, "Glucosamine and chondroitin sulfate supplementation to treat symptomatic disc degeneration: Biochemical rationale and case report," PMC, 2003. ↩

4. Khaled M. Abdelrahman, "Nutritional Supplements for the Treatment of Neuropathic Pain," PMC, 2021. ↩

5. Ibid. ↩