Magnesium L-Threonate (MgT) has shown potential benefits for brain health and cognitive function, particularly in aging and neurodegenerative conditions like Alzheimer’s Disease (AD).

Research Findings

1. Cognitive Enhancement: Studies have shown that MgT can significantly improve cognitive functions such as memory, executive function, and attention. A notable study on patients with mild to moderate dementia found that 12 weeks of MgT supplementation significantly improved cognitive function, particularly in the hippocampus and prefrontal cortex, which are critical areas for memory and executive function¹.

2. Neuroprotection: MgT has been demonstrated to exhibit neuroprotective effects against oxidative stress, a contributor to neurodegenerative diseases. In models of Alzheimer’s Disease and other neurodegenerative disorders, MgT supplementation has been shown to protect neurons and improve cognitive function²³.

3. Synaptic Density and Plasticity: MgT has been documented to increase synaptic density and plasticity in the hippocampus, enhancing both short-term and long-term memory functions⁴. This effect is crucial as a reduction in synaptic density is a hallmark of cognitive decline in aging and AD.

4. Bioavailability: Magnesium L-Threonate has higher bioavailability compared to other forms of magnesium, meaning it more effectively raises brain magnesium levels, which is essential for its cognitive benefits⁵.

Cost Consideration

While MgT is generally more expensive than other forms of magnesium supplements, its higher bioavailability and specific cognitive benefits justify the cost for those seeking to support brain health and cognitive function, especially in the context of aging and neurodegenerative conditions.

Based on the existing research, Magnesium L-Threonate appears to be a worthwhile investment for those particularly concerned with cognitive function and brain health improvement. However, it's important to consult a healthcare professional before starting any new supplement regimen.

Footnotes

1. OPEN LABEL TRIAL OF MAGNESIUM L-THREONATE IN PATIENTS WITH DEMENTIA ↩

2. Magnesium-L-threonate exhibited a neuroprotective effect against oxidative stress damage ↩

3. A Magtein®, Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults ↩

4. Enhancement of learning and memory by elevating brain magnesium ↩

5. Magnesium-L-threonate: a safer, easy-to-access, and affordable treatment ↩