Magnesium L-Threonate (MgT) is a form of magnesium that has garnered attention for its potential cognitive benefits. Here are some key findings related to its use:

1. Cognitive Enhancement: Research indicates that MgT supplementation can significantly improve memory and cognitive function in both healthy adults and individuals with cognitive impairments¹²³. Studies have demonstrated improvements in areas such as executive function, attention, verbal fluency, and memory.

2. Neuroprotective Effects: MgT has been shown to have neuroprotective properties, potentially aiding in the prevention and restoration of cognitive deficits associated with conditions like Alzheimer's disease and chronic neuropathic pain⁴⁵. It has been found to inhibit oxidative stress and inflammation, both of which are detrimental to neural health⁶.

3. Enhanced Brain Magnesium Levels: Unlike other forms of magnesium, MgT has been specifically designed to cross the blood-brain barrier effectively, significantly increasing brain magnesium levels. This elevation in brain magnesium has been linked to enhanced synaptic density and improved signaling pathways in the brain⁷⁸.

4. Gut-Brain Axis Benefits: Recent research also suggests that MgT may modulate the microbiota-gut-brain axis, contributing to its cognitive benefits. This involves altering gut microbiota composition and improving intestinal barrier function, which can influence brain health⁹.

5. Memory Restoration in Animal Models: Studies using animal models have shown that MgT can restore learning and memory functions by enhancing synaptic plasticity and reducing synaptic loss¹⁰.

Overall, Magnesium L-Threonate appears to be a promising supplement for improving cognitive function and protecting brain health, particularly in the context of aging and neurodegenerative diseases.

Footnotes

1. T.E. Wroolie, "OPEN LABEL TRIAL OF MAGNESIUM L-THREONATE IN PATIENTS WITH DEMENTIA," PMC, 2017. ↩

2. Ying Xiong, "Magnesium-L-threonate exhibited a neuroprotective effect against oxidative stress damage in HT22 cells and Alzheimer’s disease mouse model," PMC, 2022. ↩

3. Chengxiang Zhang, "A Magtein®, Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults," PMC, 2022. ↩

4. Jun Wang, "Magnesium L-threonate prevents and restores memory deficits associated with neuropathic pain by inhibition of TNF-α," PubMed, 2013. ↩

5. Wang Liao, "Magnesium L-threonate treats Alzheimer’s disease by modulating the microbiota-gut-brain axis," PMC, 2021. ↩

6. Dao-Yun Lei, "Magnesium may be an effective therapy for Alzheimer’s disease," PMC, 2022. ↩

7. Inna Slutsky, "Enhancement of learning and memory by elevating brain magnesium," PubMed, 2010. ↩

8. Chengxiang Zhang, "A Magtein®, Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults," PubMed, 2022. ↩

9. Wang Liao, "Magnesium-L-threonate treats Alzheimer’s disease by modulating the microbiota-gut-brain axis," PubMed, 2024. ↩

10. Ying Huang, "Magnesium boosts the memory restorative effect of environmental enrichment in Alzheimer’s disease mice," PMC, 2017. ↩