Magnesium L-threonate, commonly known as Magtein®, is a unique form of magnesium supplement that has been shown to effectively increase magnesium levels in the brain. This increase is important because brain magnesium is essential for supporting cognitive functions and emotional regulation¹.

Research has indicated that Magtein® can enhance synaptic plasticity and signal enhancement in brain regions crucial for cognitive abilities, such as the prefrontal cortex and hippocampus¹. This enhancement is associated with improvements in learning and memory in both young and aged individuals¹.

Additionally, Magtein® has potential benefits in managing anxiety and memory impairment[2]². By elevating brain magnesium, it may enhance cognitive functions and assist in the extinction of fear memories without affecting the amygdala-dependent fear memory³. In mouse models, Magnesium L-threonate has also been shown to relieve inflammation and gut barrier dysfunction caused by alcohol-mediated diseases while enhancing memory abilities².

Furthermore, studies suggest that Magtein® can improve cognitive functions in healthy adults and potentially reverse memory deficits associated with conditions like neuropathic pain⁴⁵.

Footnotes

1. Carlos Zarate, "New paradigms for treatment-resistant depression," PubMed Central, 2024. ↩ ↩² ↩³

2. Chang Liu, "Magnesium-L-threonate alleviate colonic inflammation and memory impairment in chronic-plus-binge alcohol feeding mice," PubMed. ↩ ↩²

3. G. Andrew Mickley, "Chronic dietary magnesium-L-threonate speeds extinction and reduces spontaneous recovery of a conditioned taste aversion," PubMed Central, 2024. ↩

4. Jun Wang, "Magnesium L-threonate prevents and restores memory deficits associated with neuropathic pain by inhibition of TNF-α," PubMed, 2024. ↩

5. Chengxiang Zhang, "A Magtein®, Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults," PubMed, 2022. ↩