I can help you find information on supplements that may help with headaches. It's important to note that persistent or severe headaches should be checked by a healthcare professional. Some supplements commonly associated with headache relief include magnesium, riboflavin (Vitamin B2), and coenzyme Q10.

I'll search for authoritative information on these supplements and their impact on headaches.

Let's start by looking up more details on each of these supplements.

Magnesium and Headaches

Magnesium has been shown to play a critical role in the management of migraines. Many studies indicate that magnesium deficiency is prevalent among migraine sufferers. Supplementation with magnesium, both orally and intravenously, has been demonstrated to reduce the frequency and intensity of migraines:

1. Intravenous Magnesium: Significantly relieves acute migraines within 15-45 minutes post-infusion¹.
2. Oral Magnesium: Regular supplementation can decrease the frequency and severity of migraines, making it a viable long-term prophylactic treatment¹².

Riboflavin (Vitamin B2) and Headaches

Riboflavin is another supplement that has shown efficacy in reducing migraines:

1. Migraine Prophylaxis: High-dose riboflavin (400 mg daily) has shown to significantly reduce the number and severity of migraine attacks³.
2. Safety and Tolerance: Riboflavin is well-tolerated with minimal side effects, making it suitable for both adults and children⁴.

Coenzyme Q10 and Headaches

Coenzyme Q10 (CoQ10) has also been found to be effective in migraine prophylaxis:

1. Reduction in Frequency and Severity: Studies indicate that CoQ10 supplementation can significantly reduce the frequency and severity of migraine attacks⁵⁶.
2. Positive Safety Profile: CoQ10 is generally well-tolerated with minimal adverse effects⁵.

Footnotes

1. Effects of Intravenous and Oral Magnesium on Reducing Migraine: A Meta-analysis of Randomized Controlled Trials - PubMed ↩ ↩²

2. Role of magnesium in the pathogenesis and treatment of migraines - PubMed ↩

3. Supplementation with Riboflavin (Vitamin B2) for Migraine Prophylaxis in Adults and Children: A Review - PubMed ↩

4. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial - PubMed ↩

5. Effectiveness of coenzyme Q10 in prophylactic treatment of migraine headache: an open-label, add-on, controlled trial - PubMed ↩ ↩²

6. [Efficacy of CoQ10 as supplementation for migraine: A meta-analysis - PubMed](https://pubmed.nc ↩